Antibody-Drug Conjugates (ADCs) Cancer Treatment
Antibody-drug conjugates stands for a promising side in cancer therapy that combines the specific monoclonal antibodies with cytotoxic drugs. The goal behind this method is for the delivery of anti-cancer agents directly to the tumor cells while reducing damage to healthy tissues.
Antibody-Drug Conjugates Consist of Three Main Components:
1. Monoclonal antibody: This is a method in which the protein attaches itself to a target antigen on the surface of cancer cells.
2. Cytotoxic drug: This is a strong anti-cancer reagent, which was in able to kill cancer cells.
3. Linker: It is a chemical bond that connects antibody and cytotoxic drug.
The Mechanism of Action of Antibody-Drug Conjugates Involves the Following Steps:
1. Binding: The monoclonal antibody attaches to the target antigen on the surface of the cancer cell.
2. Internalization: The antibody-drug conjugates is internalized into the cancer cell through endocytosis.
3. Release: Here the cytotoxic drug is propelled from the linker within cancer cell.
4. Cell death: The cytotoxic drug kills the cancerous cells.
The advantages of ADCs over traditional chemotherapy include:
1. Increased selectivity: The antibody-drug conjugates selectively targets the cancer cells with an aim to not damage healthy tissues.
2. Enhanced efficacy: It is a way of delivering cytotoxic drugs with a goal of enhancing therapeutic value.
3. Reduced toxicity: This is very selective in the sense that it only targets certain cancer cells, and targets to remove or reduce side effects.
Like all other therapies, antibody-drug conjugates has challenges also. One major issue that has been noticed in antibody-drug conjugates is the development of linkers that can effectively release cytotoxic drugs within the cancer cell while remaining stable in the bloodstream. An area that has been ongoing research is the development of antibody-drug conjugates that can overcome drug resistance mechanism. For those who know, several antibody-drug conjugates have been approved for the treatment of various cancers like breast cancer, gastric cancer among others.
WRITTEN BY:AMEDICC.COM
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